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Wed. Jun 19th, 2024

Original Antigenic Sin is responsible for better vaccine performance

By Owner Dec 13, 2022

An interesting behavior of our #immunesystem could explain #Vaccine performances against new #covid variants. #Omicron

The immune system will respond to a pathogen in a way shaped by its first exposure to it regardless of how the pathogen may have changed. In effect

When the body first encounters an infection, it produces effective antibodies against its dominant antigens and thus eliminates the condition. However, when the immune system meets the same disease, at a later evolved stage, with a new variant (with a different antigen), the immune system will still produce antibodies against this old “now recessive antigen” and not develop new antibodies against the new dominant one. This results in the production of ineffective antibodies and thus a weak immunity known as Original Antigenic Sin.

Source

https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/original-antigenic-sin-a-potential-threat-beyond-the-development-of-booster-vaccination-against-novel-sarscov2-variants/C8F4B9BE9E77EB566C71E98553579506

By Owner

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