Despite eating a healthy diet and losing a lot of weight, the blood vessels in the kidneys didn't fully recover from the disease but the blood vessels in the liver did.
A study team has found that each organ’s blood arteries are uniquely impacted by metabolic illness.
For instance, the liver and adipose tissue’s blood arteries have a difficult time processing the extra lipids, kidney vessels become metabolically dysfunctional, lung vessels become highly inflamed, and transport through the brain vessels is flawed.
Our research demonstrates how poor eating habits molecularly accelerate the development of various diseases, as vascular dysfunction underlies all major pathologies, from heart failure to atherosclerosis and neurodegeneration, said Dr. Olga Bondareva, the study’s lead author. In order to provide patients with individualised therapies in the future, we want to clarify the molecular causes of obesity, according to HI-MAG director Professor Matthias Bluher. At Leipzig University, the speaker of Collaborative Research Centre 1052 Obesity Mechanisms has long been involved in studies on morbid obesity.
Researchers from Leipzig who specialise in cardiology and laboratory medicine are also involved in this project. The next step was to determine if a healthy diet may lessen the disease-causing molecular markers brought on by an unhealthy diet. They discovered that, albeit partially, a nutritious diet can indeed enhance the molecular health of blood arteries. For instance, despite a healthy diet and significant weight loss, the blood vessels in the kidneys preserved the illness signature while the blood vessels in the liver recovered almost entirely. Accordingly, certain of our blood vessels may form a “memory” of metabolic disease that is challenging to remove.
The study of the causes and treatments for obesity has long been a focus of academic research in Leipzig. The prevention and treatment of the disease are the subject of a wide range of studies.
Leipzig is home to a large body of research on obesity, including studies on genetic correlations, metabolic problems, the mechanics of fat accumulation, the function of the brain in eating, and treatment approaches to weight loss and maintenance.